CHILDHOOD CANCER REPOSITORY

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Neuroblastoma

PDXs, ending in an "x", are patient direct and have never been in vitro. Xenografts ending in “m” are established from a cell line.

The definition for the abbreviation are given below the table. Please scroll all the way down.

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Patient-Derived Xenografts (PDX)

The Childhood Cancer Repository has patient-derived xenografts (PDXs) established from neuroblastoma, Wilm's tumor, Ewing's sarcoma, rhabdomyosarcoma, lymphoma, and acute lymphoblastic leukemia. These PDX models are available for limited distribution to investigators in immediate need of PDX models. We are working to fully characterize and expand the bank of PDXs and we will soon have more xenografts available for open distribution.

How to Request a Cell Line:

Before you begin, please open the shipping cart in a browser tab and leave that tab open until you are ready to submit your request.

Open the cell line table list pages in a second tab and make all your selections in the second tab while leaving the cart open in the first tab.

You can check your selections and make deletions from the cart in the first tab at any time.

Just click on reload or refresh in the first tab to see any changes to the cart.

When you are ready, enter your shipping information on the cart page in the first tab and submit your completed request.

(1) Select the cell line(s)/PDXs by clicking each check box next to the cell line name.
(2) Fill out the institutional or commercial/industry information at the bottom of the page.
(3) Attach a fully signed MTA (including Attachment A)
(4) Attach any additional documents required for your request (i.e. a justification for any request over 10 cell lines total)
(5) Click Submit.

For all other questions regarding your request and/or MTA, please visit our FAQ page.

To view a complete PDX description (origin, growth conditions, pictures, etc.), click on the PDX name to open a pdf data sheet to view and/or download.


dbGaP info icon Childhood Cancer Data Initiative (CCDI): Pediatric In Vivo Testing Program - Neuroblastoma
dbGaP Study Accession: phs003163.v1.p1

dbGaP info icon Childhood Cancer Data Initiative (CCDI): CCDI Pediatric In Vivo Testing Program - Leukemia
dbGaP Study Accession: phs003164.v2.p1

PDXs in our Childhood Cancer Repository which can be found in the CCDI PIVOT data are marked with a dbGaP info icon dbGaP info icon in the table below.

RequestPDXPhase of TherapySample TypeAge (yrs)SexMYCNTH mRNAGD2TMMHSTWESRNA SeqIDEXXCell Line (PDCL)Lag time DaysDoubling time Days
            PDXPDCL    
 COG-N-415x dbGaP info iconPD-PMBlood1.4F+++TERT✓✓✓✓✓✓445
 COG-N-421x dbGaP info iconPD-PMBlood2.7M+++TERT✓✓✓✓✓✓416
 COG-N-424x dbGaP info iconDxTumor 0.5M+++TERT✓✓✓✓268
 COG-N-440x dbGaP info iconPD-PMBlood0.9F+++TERT✓✓✓✓✓✓405
 COG-N-452x dbGaP info iconPD-PMBlood1.4M+++TERT✓✓✓✓✓394
 COG-N-453x dbGaP info iconPD-PMTumor1.4M+++TERT✓✓✓✓✓✓448
 COG-N-470xPD-PMBlood1.6F-++TERT✓✓✓✓✓✓768
 COG-N-471x dbGaP info iconPD-PMBlood2.6F+++TERT✓✓✓✓✓✓507
 COG-N-480x dbGaP info iconDxBM1.0M+++EST✓✓✓✓✓✓344
 COG-N-496x dbGaP info iconDxBM3.2M++TERT✓✓✓✓✓✓9514
 COG-N-518hDxBM3.3F-+UNK✓✓✓✓✓
 COG-N-519x dbGaP info iconPD-PMBlood2.0M+++TERT✓✓✓✓✓✓273
 COG-N-546xDxBM1.3F+++TERT✓✓✓✓✓✓7914
 COG-N-549x dbGaP info iconPDTumor1.2M-++TERT✓✓✓✓✓✓7313
 COG-N-557x dbGaP info iconDxTumor2.7M+++TERT✓✓✓✓✓✓13717
 COG-N-560x dbGaP info iconDxTumor 1.0M+++TERT✓✓✓✓
 COG-N-561x dbGaP info iconPD-PMBlood1.6F+++TERT✓✓✓✓✓✓579
 COG-N-564x dbGaP info iconPD-PMBloodNAF+++TERT✓✓✓✓✓✓323
 COG-N-573xDxBM2.3M+++TERT✓✓✓✓✓✓256
 COG-N-579xPDBM5.5F-++TERT✓✓✓✓✓✓545
 COG-N-590x dbGaP info iconDxTumor4.6M+++TERT✓✓✓✓✓✓547
 COG-N-603x dbGaP info iconDxTumor0.7M+++TERT✓✓✓✓✓✓296
 COG-N-615xPD-PMBloodNAM-++TERT✓✓✓✓✓✓8510
 COG-N-618x dbGaP info iconPDBM2.7M-++TERT✓✓✓✓✓✓6513
 COG-N-619x dbGaP info iconPDBM2.7M-++TERT✓✓✓✓✓✓6517
 COG-N-623x dbGaP info iconPDTumor0.7M+++TERT✓✓✓✓✓✓478
 COG-N-625x dbGaP info iconPDTumor5.0M-++ALT✓✓✓✓✓1059
 COG-N-628x dbGaP info iconDxBM2.4M+++TERT✓✓✓✓✓✓7915
 COG-N-636xDxTumor2.0M++TERT✓✓✓✓✓5010
 COG-N-653xDxTumor1.7M++-TERT✓✓✓✓✓8312
 COG-N-660xPD-PMBloodNAM-++TERT✓✓✓✓✓639
 COG-N-669xPD-PMBloodNAF-+-ALT✓✓✓✓
 COG-N-672xPD-PMBlood1.7M+++TERT✓✓✓✓✓203
 COG-N-676xPDTumor4.9M-+TERT✓✓✓
 COG-N-677xPDBM3.9M+++TERT✓✓✓✓8812
 COG-N-682xDxBM1.1F+++TERT✓✓✓✓✓216
 COG-N-683xDXBM1.1F+++TERT✓✓✓✓✓2912
 COG-N-685xPD-PMBloodNAF+++TERT✓✓✓✓✓✓606
 COG-N-697xDxTumor2.6F+++TERT✓✓✓✓✓8816
 COG-N-700xDxBM6.3F-++ALT✓✓✓✓✓✓10210
 COG-N-707xPDBMNAM++TERT✓✓✓597
 COG-N-708xDxTumor2.3F-+TERT✓✓✓✓✓628
 COG-N-709xDxTumor2.0M-+TERT✓✓✓✓7620
 COG-N-718xDxTumor6.6F++TERT✓✓✓6813
 COG-N-719xPDTumor2.3M+++TERT✓✓✓✓4513
 COG-N-731xPDBM10.3M--+TERT✓✓✓3614
 COG-N-732xDxTumor4.3F++TERT✓✓517
 COG-N-736xDxTumor2.6F++TERT✓✓✓6410
 COG-N-740xDxTumor2.0M+++TERT✓✓707
 COG-N-743xDxTumor0.9F++TERT✓✓805
 COG-N-781xPD-PMBlood2.6M-+TERT✓
 COG-N-789xDxTumor1.9M-+✓
 COG-N-791xDxTumor3.8M+++TERT✓✓869
 COG-N-804xDxTumor3.3M-+✓
 COG-N-809xDxBMNAF--✓✓337
 COG-N-813xPD-PMbloodNAM-+TERT✓✓367
 COG-N-815xPD-PMblood2.4M++TERT✓✓326
 COG-N-817xDxBM3.4F-+TERT✓
 COG-N-818xPDTumor2.3F-+✓✓10213
 COG-N-835xPDBM1.3F++✓✓418
 COG-N-845xDxBMNAM++TERT✓✓16710
 COG-N-853xPD-PMBlood1.6F+++TERT✓✓656
 COG-N-854xDxTumor0.4M++✓✓465
 Felix-PDX dbGaP info iconPD-PMBlood4.0M-++TERT✓✓✓✓✓✓597

1 - Phase of therapy for the patient at the time the specimen used to derive the cell line was obtained
Dx (Diagnosis): cell lines derived from samples of patients prior to treatment
PD (Progressive Disease): cell lines derived from samples of patients who relapsed after chemotherapy
PD-BMT: cell lines derived from samples of patients who relapsed after chemotherapy and bone marrow transplantation
PD-PM: cell lines derived from samples of post-mortem patients who relapsed after chemotherapy

2 -MYCN oncogene amplification
N: MYCN Non-Amplified
A: MYCN Amplified

3 - TP53 gene function
F: Functional
N: Non-Functional

4 - EWS/FLI1 Status
FLI1: friend leukemia insertion - chromosome 11, t(11;22)
ERG: ets-related gene - chromosome 21, t(21;22)

ALK mutation

WT: Wild Type

TMM:Telomere Maintenance mechanism

✓ = Available/available upon request

SQ- subcutaneous injection

TV- intravenous (tail vein)

EST- ever shorter telomeres, i.e. telomerase and ALT negative

TERT+- telomerase positive

ALT - alternate lengthening of telomeres, C-circle positive